Study, Year

Antibiotic Discontinuation Criteria

Nobre, 2007 [25]

ABx discontinued when PCT levels decreased by 90+% from initial value, but not prior to Day 3 (if baseline PCT measured <1 µg/L) or Day 5 (if baseline PCT measured ≥1 µg/L)

Hochreiter, 2009 [26]

ABx discontinued when PCT decreased to < 1 ng/mL, or to 25% - 35% of initial value over three days if value was >1 ng/mL

Schroeder, 2009 [27]

ABx discontinued when clinical signs of infection improved and PCT value decreased to <1 ng/mL or to <35% of initial value within three days

Bouadma, 2010 [28]

ABx discontinued when PCT concentration <80% of peak value, or absolute PCT concentration <0.5 µg/L